Cristian V.A. Munteanu, PhD
Researcher in the Bioinformatics and Structural Biochemistry Group,
Institute of Biochemistry of the Romanian Academy
ResearcherID: I-9290-2016
ScopusID: 55681217500
G. ScholarID: Cristian (V.A.) Munteanu
Position: Coordinator of IBRA protein chemistry facility (PCF)
Expertise: Analytical and preparative HPLC, nano HPLC, high-resolution mass spectrometry (MS) and tandem MS, computational mass spectrometry (R/Perl/SQL/HTML/CSS scripts or functions development for proteomics data analysis), sample preparation for MS based proteomics analysis, fundamental biochemistry and cell culture methods
Interests: Differential proteomics: investigation of protein-protein interactions in the degradation of misfolded proteins from endoplasmic reticulum in melanoma and their role in MHC class I antigen presentation with a special focus on tyrosinase and tyrosinase related proteins
Discovery proteomics and peptidomics: identification of MHC class I presented epitopes in melanoma and their mechanism of production at the molecular level
Glycoproteomics: investigation of O- and N-linked glycopeptides and glycoproteins with site-specific characterization of the occupancy and glycan heterogeneity
Chemical biology: collaborative projects in analytical chemistry, biochemistry, chemical biology
Thesis Title: Insights into functional interaction proteomics of endoplasmic reticulum associated degradation (ERAD) and antigen presentation in melanoma using mass spectrometry [Abstract]
Contact: cristian.v.a.munteanu[at] ; cristian.munteanu[at]
Scientific indicators:
> 47 ISI original articles indexed in Web of Science Core Collection

IF cumulative: > 165 (Web of Science, JCR 2021)

AIS cumulative: > 33 (Web of Science, JCR 2021)

h-index: 10 (Web of Science)/ 10 (Scopus)/ 11 (Google Scholar)

Citations: 273 (Web of Science)/ 277 (Scopus)/ 337 (Google Scholar)

Other publications: > 25 abstracts and 4 full text (3 x best poster award)

Peer-reviewer activity: Frontiers in Molecular Biosciences (Editorial Board), Biomedicine & Pharmacotherapy, Archives of Biochemistry and Biophysics, ACS Omega, Journal of Cellular and Molecular Medicine, Open Chemistry, Biomolecules, Cells, International Journal of Molecular Sciences, Pharmaceutics, Molecules

Others: Invited Evaluator for EU Joint Programme – Neurodegenerative Disease Research (JPND), peer-reviewer for the Fulbright Scholar Program, Invited member for the Judging Poster Session at the 35th anniversary edition of The Protein Society Annual Meeting (July 7-14 2021), Invited member of ACS (American Chemical Society), member of American Society for Biochemistry and Molecular Biology (ASBMB) and Romanian Society of Biochemistry and Molecular Biology (RSBMB)

Research grants: Project Director OXPROT, Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI, 2020-2022: "Defining novel potential therapeutic targets in melanoma immunobiology using a combined proteome-immunopeptidome mass-spectrometry based analysis", Project Director IMUNOPEP, Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI, 2018-2020: "Mass spectrometry based investigation of the oxidative stress as a potential key-player in the immunobiology of melanoma", member in several national and international grants. For a complete list please click here.
Selected publications: For a complete PubMed list of published articles please click here.
1.  Chiritoiu GN#, Munteanu CVA#, TA Șulea, Spiridon L, Petrescu AJ, Jandus C, Romero P, Petrescu SM, "Methionine oxidation selectively enhances T cell reactivity against a melanoma antigen", iScience; 26: 7 (107205), 2023
DOI: [10.1016/j.isci.2023.107205]
2.  Munteanu CVA*, Chiritoiu GN, Petrescu AJ, Petrescu SM*, "Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition", Front. Mol. Biosci.; 9 1061832, 2023
DOI: [10.3389/fmolb.2022.1064868]
3.  Chiritoiu GN, Chiritoiu M, Munteanu CVA*, "Dataset of human EDEM2 melanoma cells proteomics, affinity proteomics and deglycoproteomics", Data in Brief; 14: 39, 2021
DOI: [10.1016/j.dib.2021.107471]
4.  Munteanu CVA#, Chiritoiu GN#, Chiritoiu M, Ghenea S, Petrescu AJ, Petrescu SM., "Affinity Proteomics and Deglycoproteomics Uncover Novel EDEM2 Endogenous Substrates and an Integrative ERAD Network.", Mol. Cell. Proteomics; 20: 100125, 2021
DOI: [10.1016/j.mcpro.2021.100125]
5.  Chiritoiu GN#, Jandus C#, Munteanu CVA#, Ghenea S, Gannon PO, Romero P, Petrescu SM, "Epitope located N-glycans impair the MHC-I epitope generation and presentation", Electrophoresis; 37(11): 1448-60, 2016
DOI: [10.1002/elps.201500449]
Book chapters: 1.  Munteanu CVA#, Chiritoiu GN#, Petrescu AJ, Petrescu SM., "Profiling Optimal Conditions for Capturing EDEM Proteins Complexes in Melanoma Using Mass Spectrometry", Adv Exp Med Biol.;1140: 155-167, 2019
DOI: [10.1007/978-3-030-15950-4_9]
2.  Albulescu R, Petrescu AJ, Sarbu M, Grigore A, Ica R, Munteanu CVA, Albulescu A, Militaru IV, Zamfir AD, Petrescu SM, Tanase C "Mass Spectrometry for Cancer Biomarkers", Proteomics Technologies and Applications; 1-29, 2019
DOI: [10.5772/intechopen.85609]
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Disclaimer: This material does not necessarily represent the official position of the Institute of Biochemistry of the Romanian Academy (IBRA) or any other official institution.
# These author contributed equally to this work.
*Corresponding author.
Last update: 23/07/2023.