Cristian V.A. Munteanu, PhD
Researcher in the Bioinformatics and Structural Biochemistry Group,
Institute of Biochemistry of the Romanian Academy
ResearcherID: I-9290-2016
G. ScholarID: Cristian (V.A.) Munteanu
Position: Coordinator of IBAR mass spectrometry facility
Expertise: Analytical and preparative HPLC, nano HPLC, high-resolution mass spectrometry (MS) and tandem MS, computational mass spectrometry (R/Perl/SQL scripts or functions development for proteomics data analysis), sample preparation for MS based proteomics analysis, fundamental biochemistry and cell culture methods
Interests: Differential proteomics: investigation of protein-protein interactions in the degradation of misfolded proteins from endoplasmic reticulum in melanoma and their role in MHC class I antigen presentation with a special focus on tyrosinase and tyrosinase related proteins
Discovery proteomics and peptidomics: identification of MHC class I presented epitopes in melanoma and their mechanism of production at the molecular level
Glycoproteomics: investigation of O- and N-linked glycopeptides and glycoproteins with site-specific characterization of the occupancy and glycan heterogeneity
Thesis Title: Insights into functional interaction proteomics of endoplasmic reticulum associated degradation (ERAD) and antigen presentation in melanoma using mass spectrometry [Abstract]
Contact: ;
Scientific indicators:
25 ISI original articles indexed in Web of Science Core Collection

IF cumulative: 67.38 (Web of Science, JCR 2018)

AIS cumulative: 14 (Web of Science, JCR 2018)

h-index: 5 (Web of Science)/ 6 (Google Scholar)

Citations: 85 (Web of Science)/ 90 (Google Schoolar)

Other publications: 20 abstracts and 4 full text (2 x best poster award)

Research grants: Project director IMUNOPEP, Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI, 2018–2020 "Mass spectrometry based investigation of the oxidative stress as a potential key-player in the immunobiology of melanoma", Member in 2 international grants (TYRPRES, Romanian-Swiss Project IZERZ0_142216, 2012–2015 "Role of the ERAD pathway in the degradation of tyrosinase and production of antigenic peptides in human melanoma", LYSOMOD_734825 2017-2021 – “Genetic and Small Molecule Modifiers of Lysosomal Function”) and member in 2 national grants

Selected publications: 1.  Chirițoiu M#, Chirițoiu GN#, Munteanu CVA#, Pastramă F, Ivessa EN, Petrescu SM, “EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired", Int. J. Mol. Sci.; 21(10): E3468, 2020
DOI: [10.3390/IJMS21103468]
2.  Sima LE, Chirițoiu GN, Neguț I, Grumezescu V, Orobeti Ș, Munteanu CVA, Sima F, Axente E, “Functionalized Graphene Oxide Thin Films for Anti-tumor Drug Delivery to Melanoma CellsFunctionalized Graphene Oxide Thin Films for Anti-tumor Drug Delivery to Melanoma Cells", Front Chem.; 8: 184, 2020
DOI: [10.3389/FCHEM.2020.00184]
3.  Gheorghe RO, Deftu A, Filippi A, Grosu A, Bica-Popi M, Chirițoiu M, Chirițoiu G, Munteanu CVA, Silvestro L, Ristoiu V, “Silencing the Cytoskeleton Protein Iba1 (Ionized Calcium Binding Adapter Protein 1) Interferes with BV2 Microglia Functioning", Cell Mol Neurobiol.; in press, 2020
DOI: [10.1007/s10571-020-00790-w]
4.  Ica R, Petruț A, Munteanu CVA, Sârbu M, Vukelić Ž, Petrica L, Zamfir AD. “Orbitrap mass spectrometry for monitoring the ganglioside pattern in human cerebellum development and aging", J Mass Spectrom.;55: e4502, 2020
DOI: [10.1007/10.1002/jms.4502]
5.  Munteanu CVA#, Chirițoiu GN#, Petrescu AJ, Petrescu SM, “Profiling Optimal Conditions for Capturing EDEM Proteins Complexes in Melanoma Using Mass Spectrometry", Adv Exp Med Biol.; 1140: 156-167, 2019
DOI: [10.1007/978-3-030-15950-4_9]
6.  Ionescu AE, Mențel M, Munteanu CVA, Sima LE, Martin EC, Necula-Petrăreanu G, Szedlacsek SE.,“Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation", Int J Mol Sci.; 20: 6307, 2019
DOI: [10.3390/ijms20246307]
7.  Sârbu M, Ica R, Petruț A, Vukelić Ž, Munteanu CVA, Petrescu AJ, Zamfir AD, “Gangliosidome of human anencephaly: A high resolution multistage mass spectrometry study", Biochimie; 163: 142-151, 2019
DOI: [10.1016/j.biochi.2019.05.017]
8.  Tănase CI, Cocu FG, Drăghici C, Hanganu A, Pintilie L, Măganu M, Munteanu CVA, Șova S, “Secondary Compounds in the Catalytic Hydrogenation of Enone and Allylic Alcohol Prostaglandin Intermediates: Isolation, Characterization, X-Ray Crystallography", New Journal of Chemistry; 43: 7582-7599, 2019
DOI: [10.1039/C9NJ01186B]
9.  Sârbu M, Dehelean L, Munteanu CVA, Petrescu AJ, Zamfir AD “Human caudate nucleus exhibits a highly complex ganglioside pattern as revealed by high-resolution multistage Orbitrap MS", Journal of Carbohydrate Chemistry; in press, 2019
DOI: [10.1080/07328303.2019.1669632]
10.  Tănase CI, Drăghici C, Șova S, Hanganu A, Gal E, Munteanu CVA, “A long- range tautomeric effect on a new Schiff isoniazid analogue, evidenced by NMR study and X- ray crystallography", New Journal of Chemistry; 42: 14459-14468, 2018
DOI: [10.1039/C8NJ01680A]
11.  Vlaicu O, Șelescu T, Pastramă F, Munteanu CVA, Riva L, Dubuisson J., Rouille Y, Popescu CI, “Novel replicons and trans-encapsidation systems for Hepatitis C Virus proteins live imaging and virus-host interaction proteomics", Journal of Virological Methods; 246: 42-50, 2017
DOI: [10.1016/j.jviromet.2017.04.009]
12.  Sârbu M, Dehealean L, Munteanu CVA, Vukelic Z, Zamfir AD, “Assessment of ganglioside age-related and topographic specificity in human brain by Orbitrap mass spectrometry", Analytical Biochemistry; 15(521): 40-54, 2017
DOI: [10.1016/j.ab.2017.01.010]
13.  Chirițoiu GN#, Jandus C#, Munteanu CVA#, Ghenea S, Gannon PO, Romero P, Petrescu SM, “Epitope located N-glycans impair the MHC-I epitope generation and presentation", Electrophoresis; 37(11): 1448-60, 2016
DOI: [10.1002/elps.201500449]
14.  Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F#, Munteanu CVA#, Negroiu G, "Cross-talk between DopaChromeTautomerase and Caveolin-1 is Melanoma Cell Phenotype Specific and Potentially Involved in Tumor Progression", Journal of Biological Chemistry; 291(24): 12481-500, 2016
DOI: [10.1074/jbc.M116.714733]
15.  Sârbu M, Munteanu CVA, Dehelean L, Petrescu AJ, Peter-Katalinic J, Zamfir AD, "Identification and structural characterization of novel O- and N-glycoforms in the urine of a Schindler disease patient by Orbitrap mass spectrometry", Journal of Mass Spectrometry; 50(9): 1044-56, 2015
DOI: [10.1002/jms.3616]
16.  Robu AC, Popescu L, Munteanu CVA, Seidler DG, Zamfir AD, "Orbitrap mass spectrometry characterization of hybrid chondroitin/dermatan sulfate hexasaccharide domains expressed in brain", Analytical Biochemistry; 485: 122-31, 2015
DOI: [10.1016/j.ab.2015.06.028]
17.  Tănase CI, Draghici C, Shova S, Cojocaru A, Maganu M, Munteanu CVA, Cocu F, "Regioselective reactions on a 1,3-disubstituted dihydroxymethyl or dicarboxyl hexahydropentalene skeleton", Tetrahedron; 71(38): 6852-59, 2015
DOI: [10.1016/j.tet.2015.07.021]
18.  Tănase CI, Draghici C, Caproiu, MT, Shova, S, Cojocaru A, Munteanu CVA, "MCPB treatment of (±)-(1α,3α,3aβ,6aβ)-1,2,3,3a,4,6a-hexahydro-1,3-pentalenedimethanol and its O-acyl-protected derivatives; X-ray crystallography", Tetrahedron; 71(24): 4154-62, 2015
DOI: [10.1016/j.tet.2015.04.096]
19.  Petrăreanu G, Bălașu MC, Văcaru AM, Munteanu CVA, Ionescu AE, Matei I, Szedlacsek SE, "Phosphoketolases from Lactococcus lactis, Leuconostoc mesenteroides and Pseudomonas aeruginosa: Dissimilar sequences, similar substrates but distinct enzymatic characteristics", Applied Microbiology and Biotechnology; 98(18): 7855-67, 2014
DOI: [10.1007/s00253-014-5723-6]
Book chapters: 1.  Albulescu R, Petrescu AJ, Sârbu M, Grigore A, Ica R, Munteanu CVA, Albulescu A, Militaru IV, Zamfir AD, Petrescu SM, Tănase C “Mass Spectrometry for Cancer Biomarkers", Proteomics Technologies and Applications; : in press, 2019
DOI: [10.5772/intechopen.85609]
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Disclaimer: This material does not necessarily represent the official position of the Institute of Biochemistry of the Romanian Academy (IBAR) or any other official institution.
# These author contributed equally to this work.