Cristian V.A. Munteanu, PhD
Researcher in the Bioinformatics and Structural Biochemistry Group,
Institute of Biochemistry of the Romanian Academy
ResearcherID: I-9290-2016
Position: Coordinator of IBAR mass spectrometry facility
Expertise: Analytical and preparative HPLC, nano HPLC, high-resolution mass spectrometry (MS) and tandem MS, computational mass spectrometry (R/Perl/SQL scripts or functions development for proteomics data analysis), sample preparation for MS based proteomics analysis, fundamental biochemistry and cell culture methods
Interests: Differential proteomics: investigation of protein-protein interactions in the degradation of misfolded proteins from endoplasmic reticulum in melanoma and their role in MHC class I antigen presentation with a special focus on tyrosinase and tyrosinase related proteins
Discovery proteomics and peptidomics: identification of MHC class I presented epitopes in melanoma and their mechanism of production at the molecular level
Glycoproteomics: investigation of O- and N-linked glycopeptides and glycoproteins with site-specific characterization of the occupancy and glycan heterogeneity
Thesis Title: Insights into functional interaction proteomics of endoplasmic reticulum associated degradation (ERAD) and antigen presentation in melanoma using mass spectrometry [Abstract]
Contact: ;
Scientific indicators:
20 ISI original articles indexed in Web of Science Core Collection

IF cumulative: 49.15 (Web of Science, JCR 2018)

AIS cumulative: 9.75 (Web of Science, JCR 2018)

h-index: 5 (Web of Science)

Citations: 73 (Web of Science)

Other publications: 20 abstracts and 4 full text (2 x best poster award)

Research grants: Project director IMUNOPEP, Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI, 2018–2020 "Mass spectrometry based investigation of the oxidative stress as a potential key-player in the immunobiology of melanoma", Member in 2 international grants (TYRPRES, Romanian-Swiss Project IZERZ0_142216, 2012–2015 "Role of the ERAD pathway in the degradation of tyrosinase and production of antigenic peptides in human melanoma", LYSOMOD_734825 2017-2021 – “Genetic and Small Molecule Modifiers of Lysosomal Function”) and member in 2 national grants

Selected publications: 1.  Munteanu CVA#, Chirițoiu GN#, Petrescu AJ, Petrescu SM, “Profiling Optimal Conditions for Capturing EDEM Proteins Complexes in Melanoma Using Mass Spectrometry", Adv Exp Med Biol.; 1140: 156-167, 2019
DOI: [10.1007/978-3-030-15950-4_9]
2.  Sârbu M, Ica R, Petruț A, Vukelić Ž, Munteanu CVA, Petrescu AJ, Zamfir AD, “Gangliosidome of human anencephaly: A high resolution multistage mass spectrometry study", Biochimie; 163: 142-151, 2019
DOI: [10.1016/j.biochi.2019.05.017]
3.  Tănase CI, Cocu FG, Drăghici C, Hanganu A, Pintilie L, Măganu M, Munteanu CVA, Șova S, “Secondary Compounds in the Catalytic Hydrogenation of Enone and Allylic Alcohol Prostaglandin Intermediates: Isolation, Characterization, X-Ray Crystallography", New Journal of Chemistry; 43: 7582-7599, 2019
DOI: [10.1039/C9NJ01186B]
4.  Sârbu M, Dehelean L, Munteanu CVA, Petrescu AJ, Zamfir AD “Human caudate nucleus exhibits a highly complex ganglioside pattern as revealed by high-resolution multistage Orbitrap MS", Journal of Carbohydrate Chemistry; in press, 2019
DOI: [10.1080/07328303.2019.1669632]
5.  Tănase CI, Drăghici C, Șova S, Hanganu A, Gal E, Munteanu CVA, “A long- range tautomeric effect on a new Schiff isoniazid analogue, evidenced by NMR study and X- ray crystallography", New Journal of Chemistry; 42: 14459-14468, 2018
DOI: [10.1039/C8NJ01680A]
6.  Vlaicu O, Șelescu T, Pastramă F, Munteanu CVA, Riva L, Dubuisson J., Rouille Y, Popescu CI, “Novel replicons and trans-encapsidation systems for Hepatitis C Virus proteins live imaging and virus-host interaction proteomics", Journal of Virological Methods; 246: 42-50, 2017
DOI: [10.1016/j.jviromet.2017.04.009]
7.  Sârbu M, Dehealean L, Munteanu CVA, Vukelic Z, Zamfir AD, “Assessment of ganglioside age-related and topographic specificity in human brain by Orbitrap mass spectrometry", Analytical Biochemistry; 15(521): 40-54, 2017
DOI: [10.1016/j.ab.2017.01.010]
8.  Chirițoiu GN#, Jandus C#, Munteanu CVA#, Ghenea S, Gannon PO, Romero P, Petrescu SM, “Epitope located N-glycans impair the MHC-I epitope generation and presentation", Electrophoresis; 37(11): 1448-60, 2016
DOI: [10.1002/elps.201500449]
9.  Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F#, Munteanu CVA#, Negroiu G, "Cross-talk between DopaChromeTautomerase and Caveolin-1 is Melanoma Cell Phenotype Specific and Potentially Involved in Tumor Progression", Journal of Biological Chemistry; 291(24): 12481-500, 2016
DOI: [10.1074/jbc.M116.714733]
10.  Sârbu M, Munteanu CVA, Dehelean L, Petrescu AJ, Peter-Katalinic J, Zamfir AD, "Identification and structural characterization of novel O- and N-glycoforms in the urine of a Schindler disease patient by Orbitrap mass spectrometry", Journal of Mass Spectrometry; 50(9): 1044-56, 2015
DOI: [10.1002/jms.3616]
11.  Robu AC, Popescu L, Munteanu CVA, Seidler DG, Zamfir AD, "Orbitrap mass spectrometry characterization of hybrid chondroitin/dermatan sulfate hexasaccharide domains expressed in brain", Analytical Biochemistry; 485: 122-31, 2015
DOI: [10.1016/j.ab.2015.06.028]
12.  Tănase CI, Draghici C, Shova S, Cojocaru A, Maganu M, Munteanu CVA, Cocu F, "Regioselective reactions on a 1,3-disubstituted dihydroxymethyl or dicarboxyl hexahydropentalene skeleton", Tetrahedron; 71(38): 6852-59, 2015
DOI: [10.1016/j.tet.2015.07.021]
13.  Tănase CI, Draghici C, Caproiu, MT, Shova, S, Cojocaru A, Munteanu CVA, "MCPB treatment of (±)-(1α,3α,3aβ,6aβ)-1,2,3,3a,4,6a-hexahydro-1,3-pentalenedimethanol and its O-acyl-protected derivatives; X-ray crystallography", Tetrahedron; 71(24): 4154-62, 2015
DOI: [10.1016/j.tet.2015.04.096]
14.  Petrareanu G, Balasu MC, Vacaru AM, Munteanu CVA, Ionescu AE, Matei I, Szedlacsek SE, "Phosphoketolases from Lactococcus lactis, Leuconostoc mesenteroides and Pseudomonas aeruginosa: Dissimilar sequences, similar substrates but distinct enzymatic characteristics", Applied Microbiology and Biotechnology; 98(18): 7855-67, 2014
DOI: [10.1007/s00253-014-5723-6]
Book chapters: 1.  Albulescu R, Petrescu AJ, Sârbu M, Grigore A, Ica R, Munteanu CVA, Albulescu A, Militaru IV, Zamfir AD, Petrescu SM, Tănase C “Mass Spectrometry for Cancer Biomarkers", Proteomics Technologies and Applications; : in press, 2019
DOI: [10.5772/intechopen.85609]
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Disclaimer: This material does not necessarily represent the official position of the Institute of Biochemistry of the Romanian Academy (IBAR) or any other official institution.